Clara Connell, D.O., Arizona Center for Aging, University of Arizona/Banner Health
|TIPS FOR DEALING WITH DIARRHEA AND FECAL INCONTINENCE IN OLDER ADULTS
Diarrhea is defined as an abnormal increase in stool liquidity, stool frequency (>3-5 stools per day), and stool weight (>200 grams per day). Diarrheal illness is the second most common cause of death worldwide and one of the four most common infectious illnesses among elderly nursing home residents in the US.
Acute diarrhea is defined as diarrhea that resolves within 7-14 days. Chronic diarrhea is diarrhea lasting more than 3-4 weeks. Diarrhea is also classified by etiology/pathophysiologic mechanism and further classified by its cause. Common causes in older adults are discussed below.
Finally, diarrhea can be characterized with the Bristol Scale, which describes stool quality on a scale from 1 (separate hard lumps) to 7 (watery with no solid pieces). Scores of 5-7 indicate diarrhea.
No matter what the cause or classification, diarrhea for even a short time (2-3 days), if associated with fever, dehydration, or weight loss, may become life-threatening, particularly in frail older adults.
Common Causes in Older Adults
A wide variety of conditions can cause diarrhea in older adults. They range from common causes, like infection, to less common causes, like autoimmune and endocrine disorders.
Infectious Diarrhea typically has an abrupt onset. The etiology can be bacterial, viral, or parasitic. The infection may be acquired from other individuals, contaminated food or water, or during travel. In nursing homes, infectious diarrhea is highly likely when multiple individuals have diarrhea in close temporal proximity. While most diarrheal infections in older adults are viral, bloody diarrhea should raise concern about of bacterial infection and appropriate microbiological studies should be obtained. If a patient was recently hospitalized or has been taking antibiotics, C difficile is a possible cause and C diff toxin assays should be ordered.
Medications are another common cause. In some cases the offending medication is obvious, such as when patients are taking laxatives, magnesium-containing antacids, or antibiotics that cause diarrhea. Other medications notable for causing diarrhea in older adults are anticonvulsants, antipsychotics, and certain antineoplastic agents.
Fecal Impaction, paradoxically, can also cause diarrhea, with liquid feces leaking around the around the impacted stool. Impaction can be due to medications that reduce bowel motility (eg, opioids, antipsychotics, iron, calcium blockers), constipation due to hypothyroidism or inadequate fiber/fluid intake, or neoplasms, strictures, or bowel motility disorders.
Osmotic Diarrhea occurs when there is ingestion of poorly absorbed solutes, leading to malabsorption. Examples include lactose intolerance, celiac disease, and pancreatic dysfunction.
Systemic Disorders can also cause diarrhea. Hyperthyroidism is one example. Other examples include inflammatory bowel disease (ulcerative colitis and Crohn’s disease) While often associated with younger individuals, the prevalence of inflammatory bowel disease is increasing in older adults. And, as discussed below, cancer should also be in the differential diagnosis.
Acute diarrhea is most often due to an infection or a newly prescribed medication and it can be evaluated as discussed above. The cause of chronic diarrhea, however, is not always obvious because symptoms of systemic disorders may be subtle in older adults, or because some patients may be unable to give a good history.
Patients with chronic diarrhea who have rectal bleeding, melena, progressive abdominal pain, unexplained weight loss, or other systemic symptoms may have colon cancer or inflammatory bowel disease (IBD). Assuming their overall health is such that diagnosis and treatment are appropriate, they should be referred to endoscopic evaluation.
Certain lab abnormalities should also prompt consideration of cancer or IBD. These include iron deficiency anemia, a positive fecal occult bleed test, an elevated erythrocyte sedimentation rate, or increased levels of C-reactive protein, or fecal calprotectin. Patients with any of these findings should be considered for endoscopic evaluation.
Other considerations in older adults with chronic diarrhea include a myriad of conditions. They include hyperthyroidism (including subclinical hyperthyroidism, which occurs in older adults), unreported or surreptitious laxative abuse (which can be detected with a fecal laxative assay), and osmotic diarrhea, which is diagnosed by measuring the stool osmotic gap; a gap >50 mEq/L suggests osmotic diarrhea.
Regardless of the cause, the highest treatment priority is to correct fluid and electrolyte abnormalities. Parenteral fluid containing NaCl, KCl, and glucose are generally used. Commercially available oral rehydration solutions can be used if diarrhea/dehydration are not severe. Care should be taken, however, to avoid over-hydration when parental fluids are used, particularly in patients with heart failure or renal dysfunction.
Underlying causes should be treated when possible, such as administering antibiotics for C. difficile infection, steroids or aminosalicylate drugs (5-ASA) for inflammatory bowel disease, or a gluten free diet for celiac disease.
Symptomatic treatment may be also needed. Oral loperamide, bismuth subsalicylate, or cholestyramine may decrease diarrhea. They should be avoided, however in patients with bloody diarrhea or if C. difficile infection or ischemic colitis is suspected.
Fecal incontinence is defined as the involuntary passage of solid or liquid feces. In elderly community dwelling patients, the prevalence is 17%, with higher rates in nursing home residents and hospitalized elderly. The true prevalence is likely even higher, however, due to reluctance of patients to report symptoms, mistaking fecal incontinence for diarrhea, as well as clinicians not asking about fecal incontinence during routine histories. Risk factors include prior episodes of fecal incontinence, fecal urgency, diabetes mellitus, hormone therapy, and diarrhea.
Classification - There are several types of fecal incontinence. Urge incontinence (urge to void with inability to get to the bathroom on time) is seen in conditions causing weakness of the external anal sphincter. Passive (stress) incontinence occurs in conditions causing weakness of the internal anal sphincter; fecal leakage can occur with coughing or sneezing. Overflow incontinence occurs when there is constipation or impaction; liquid stool builds up behind the obstructing feces and leaks around it.
Evaluation of fecal incontinence starts with a rectal exam to exclude fecal impaction and assess sphincter function, along with a neurological exam. Also take a medication history, as numerous medications can cause fecal incontinence. If no cause is identified with history and physical, endoscopy to exclude colitis or cancer is an appropriate next step. Incontinence severity can be measured, and treatment effectiveness monitored, with the Wexner score.
Anorectal manometry, along with ultrasound and MRI, can identify defects in the internal and external sphincters. Defecography (x-ray imaging of the rectum and anus during defecation) should be performed in refractory cases to assess for enteroceles, rectoceles, and rectal prolapse.
Treatment, if no reversible cause is identified, can involve several approaches. Consider habit training (regularly scheduled defecation), which is particularly useful for patients with dementia. For passive incontinence, consider physical therapy for pelvic floor muscle (sphincter) training, which can be aided by biofeedback. Skin protection with barrier creams should be considered for all patients.
Anti-diarrheals, like loperamide, bismuth subsalicylate, or cholestyramine, may reduce stool frequency and incontinence. Suppositories or enemas can be used in the case of overflow fecal incontinence due to constipation.
For selected patients, other treatments include anal plugs, injectable agents to bulk up the sphincters, application of radiofrequency energy that causes remodeling of the rectal mucosa, and surgery to repair rectal prolapse or sphincter damage.
References and Resources
- Bharucha AE, Dunivan G, Goode PS, et al. Epidemiology, pathophysiology, and classification of fecal incontinence: state of the science summary for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) workshop. Am J Gastroenterol. 2015;110(1):127–136
- Brown HW, et al. If we don't ask, they won't tell: Screening for urinary and fecal incontinence by primary care providers. J Am Board Fam Med. 2018;31(5):774–782.
- Crooks B. How to manage chronic diarroea in the elderly? BMJ Frontline Gastroenterology. 2019. http://dx.doi.org/10.1136/flgastro-2018-101097
- Hadie R, Prasad S, Chokhavatia S. Clinical challenges of fecal incontinence in the elderly. Curr Treat Options Gastro (2015)13:287-300.
- Parker CH, Henry S, Liu LWC. Efficacy of biofeedback therapy in clinical practice for the management of chronic constipation and fecal incontinence. J Can Assoc Gastroenterol. 2019;2(3):126-131
- Sabol VK, Carlson KK. Diarrhea. Applying research to bedside practice. AACN Advanced Critical Care 18:32-34, 2007.Saldana Ruiz N, Kaiser AM. Fecal incontinence - Challenges and solutions. World J Gastroenterol. 2017;23(1):11–24.